In this 2017 ICAP Grand Rounds Webinar Presentation, Claude Ann Mellins, Ph.D., of the HIV Center for Clinical and Behavioral Studies at the New York State Psychiatric Institute & Columbia University, discusses the importance of promoting health of adolescents who have grown up with HIV. Due to the scarcity of evidence-based interventions, Dr. Mellins suggests conducting cross-cultural studies of cognitive and behavioral health needs, and developing evidence-based interventions to promote youth health and well-being, and support families.